Neuropharmacological characterization of local ibogaine effects on dopamine release.
Journal of neural transmission (Vienna, Austria : 1996) January 1, 1996 M S Reid, K Hsu, K H Souza et al. 19 citations
In rats, ibogaine applied directly to the nucleus accumbens or striatum via microdialysis had a biphasic effect on extracellular dopamine: lower doses (10⁻⁶ M–10⁻⁴ M) decreased dopamine levels, while higher doses (5×10⁻⁴ M–10⁻³ M) increased them. The dopamine metabolite DOPAC was unaffected. Co-administration with naloxone or norbinaltorphimine blocked the dopamine decrease, suggesting involvement of kappa opioid receptors. The stimulatory effect at high doses was calcium-independent, not blocked by tetrodotoxin, but reduced by cocaine, reserpine, or alpha-methyl-para-tyrosine pretreatment. In striatal synaptosomes, ibogaine and harmaline inhibited dopamine uptake dose-dependently, indicating the stimulatory effect involves the dopamine transporter.