Gangliosides attenuate stress-induced changes on body weight, motor activity and on the behavioral response to 5-methoxy-N,N-dimethyltryptamine.
Brain research bulletin January 1, 1996 L M Cancela, M Volosin, V A Molina 14 citations
Injecting gangliosides before repeated restraint stress in rats reversed stress-induced reductions in motor activity and body weight, and enhanced certain behavioral responses linked to serotonin receptors. A single stress session or three days of stress alone did not change the response to a serotonin-receptor drug, but combining gangliosides with three days of stress increased forepaw treading and hindlimb abduction. Gangliosides may speed up adaptive changes in serotonin-1 sites and lessen some aftereffects of stress.