Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats.
Pharmacology, biochemistry, and behavior November 1, 1995 A H Rezvani, D H Overstreet, Y W Lee 136 citations
Ibogaine, injected into the abdomen or given orally, but not under the skin, reduced alcohol intake in alcohol-preferring, Fawn-Hooded, and alcohol-accepting rats. The effect was dose-dependent and did not diminish with repeated oral doses over five days. Ibogaine did not affect blood alcohol levels or food and water intake. The results suggest that ibogaine or its metabolites may reduce alcohol consumption by modulating brain chemicals involved in alcohol intake regulation, though the exact mechanism is not fully understood.