Tissue distribution, metabolism and effects of bufotenine administered to rats.
Neuropharmacology July 1, 1995 R W Fuller, H D Snoddy, K W Perry 37 citations
Bufotenine, a serotonin analog, was injected into rats at doses of 1, 30, or 100 mg/kg. One hour later, concentrations were highest in lung, heart, and blood, and lower in brain and liver. Bufotenine was nearly gone by 8 hours. It was slightly higher in hypothalamus and brain stem than in striatum or cortex; serotonin decreased slightly while its metabolite 5HIAA increased in those regions. Type A monoamine oxidase, not type B, metabolizes bufotenine. Bufotenine raised serum corticosterone, an effect not blocked by metergoline. Over 99% of bufotenine was in platelet-poor plasma, indicating it is not stored in platelets. Bufotenine penetrates the blood-brain barrier poorly and is rapidly eliminated.