Effects of ibogaine on sensory-motor function, activity, and spatial learning in rats.
Pharmacology, biochemistry, and behavior May 1, 1995 R P Kesner, P Jackson-Smith, C Henry et al. 25 citations
Ibogaine, a naturally occurring alkaloid, reduces withdrawal symptoms from morphine but also impairs sensory-motor function, activity, and learning in rats. At doses of 20-60 mg/kg, rats showed slower response times and motor reflex impairments at 40-60 mg/kg. Locomotor and nonlocomotor activity, as well as emotionality, were reduced at 10-40 mg/kg, with near-inactivity at higher doses. Learning a spatial location task was also impaired, likely due to reduced activity and sensory detection. A single 40 mg/kg injection caused learning deficits 1 day after, but not 7 days after, without affecting sensory-motor function at those times. Thus, ibogaine produces acute sensory-motor and activity problems and long-term learning deficits without lasting sensory-motor changes.