Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats.
Psychopharmacology February 1, 1995 S I Dworkin, S Gleeson, D Meloni et al. 49 citations
Ibogaine, an indole alkaloid proposed for treating drug abuse, suppressed lever pressing for food, cocaine, and heroin in rats under a fixed-ratio schedule of reinforcement. A high dose (80 mg/kg) given 60 minutes before sessions reduced food-reinforced responding by 97%, with lingering effects the next day. Cocaine self-administration was suppressed only by 80 mg/kg given 60 or 90 minutes before sessions, with the longer pretreatment suppressing responding for 48 hours; lower doses or earlier pretreatment had no effect. Heroin self-administration was most sensitive: both 40 and 80 mg/kg almost completely suppressed responding after 60 minutes, but responding returned to control levels the next day.