Ibogaine possesses a selective affinity for sigma 2 receptors.
Life sciences January 1, 1995 R H Mach, C R Smith, S R Childers 145 citations
Ibogaine, an alkaloid that may reduce cravings for addictive drugs, binds more strongly to sigma-2 receptors (Ki = 90.4 and 250 nM) than to sigma-1 receptors (Ki = 9310 nM). This suggests sigma-2 receptors could be its primary target in the central nervous system, and its low affinity for sigma-1 receptors makes it a promising starting point for developing drugs selective for sigma-2 receptors.