The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine.
Behavioural brain research November 16, 1994 S L Cappendijk, D Fekkes, M R Dzoljic 57 citations
In morphine-dependent rats, norharman (20 mg/kg) and ibogaine (40 mg/kg) each reduced the severity of withdrawal symptoms triggered by naloxone (4 mg/kg). Specific signs including teeth-chattering, chewing, penile licking, and diarrhea were lessened by both compounds. Norharman additionally decreased withdrawal-related grooming and rearing. The findings suggest that both norharman and ibogaine can inhibit opioid withdrawal syndrome.