Ibogaine modulates cocaine responses which are altered due to environmental habituation: in vivo microvoltammetric and behavioral studies.
Pharmacology, biochemistry, and behavior November 1, 1994 P A Broderick, F T Phelan, F Eng et al. 46 citations
Ibogaine reduced cocaine-induced increases in dopamine release in the nucleus accumbens and amplified cocaine-induced decreases in serotonin release in male rats. It also diminished cocaine-stimulated ambulation and central ambulation, behaviors that had habituated over time in the test chamber. Rearing and fine movements, which did not habituate, were not affected by ibogaine. Ibogaine alone did not significantly alter dopamine release over two hours but did increase serotonin release and acted as a weak psychostimulant. The findings highlight a modulatory role for serotonin in ibogaine-cocaine interactions and show ibogaine's efficacy when cocaine responses are reduced by environmental habituation.