Alpha-adrenergic and 5-HT2-serotonergic effects of some beta-phenylethylamines on isolated rat thoracic aorta.
General pharmacology January 1, 1994 P Saez, Y Borges, E Gonzalez et al. 21 citations
Several phenylethylamine compounds cause concentration-dependent contraction of isolated rat thoracic aorta, with varying potency: 2C-H (pD2 = 6.74) is most potent, followed by TMPEA (pD2 = 5.83), 2C-D (pD2 = 5.06), homoveratrylamine (pD2 = 4.46), and homopiperonylamine (pD2 = 4.19). At a concentration of 9.9 × 10⁻⁶ M, 2C-N acts as a competitive antagonist to serotonin in this tissue. Comparing these results with earlier findings for 2C-B, weak or partial agonistic activity or antagonism of aortic contraction appears to relate to the psychedelic properties reported in humans for phenylethylamines.