Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors.
European journal of pharmacology November 9, 1993 A A Alhaider, M Hamon, G L Wilcox 15 citations
Intrathecal injection of 5-MeO-DMT, a serotonin receptor agonist, produces antinociceptive (pain-blocking) effects in mice across three behavioral tests: tail-flick, substance P, and NMDA assays. It prolonged tail-flick latency at doses of 4.6-92 nmol per mouse, an effect blocked by 5-HT3 and GABAA receptor antagonists but not by several other serotonin receptor blockers. 5-MeO-DMT inhibited biting behavior and increased scratching induced by substance P; the inhibition of biting was antagonized by 5-HT1B and GABAA antagonists, while enhanced scratching involved multiple serotonin and GABAA receptors. NMDA-induced biting was also inhibited by 5-MeO-DMT, blocked by 5-HT1B, 5-HT3, and GABAA antagonists. These findings suggest 5-MeO-DMT may promote serotonin release.