Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.
European journal of pharmacology November 2, 1993 M D Schechter, T L Gordon 33 citations
Rats were trained to distinguish the effects of ibogaine, a hallucinogenic alkaloid used in West Central Africa and studied for treating chemical dependency, from a placebo. Ibogaine from three different suppliers (Sigma Chemical Co., the National Institute on Drug Abuse, and NDA International Inc.'s Endabuse) produced similar discrimination in the rats, with effective doses ranging from 2.5 to 3.4 mg/kg. Other drugs tested, including those affecting dopamine and serotonin systems, did not produce ibogaine-like effects. The findings suggest that ibogaine from these sources is comparable for preclinical research.