The serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine facilitates noradrenaline release from rat spinal cord slices and inhibits monoamine oxidase activity.
General pharmacology March 1, 1993 W Reimann, F Schneider 17 citations
The compound 5-methoxy-N,N-dimethyltryptamine (MeODMT) strengthens noradrenergic signaling in the rat spinal cord through two distinct mechanisms: it facilitates the release of noradrenaline triggered by electrical stimulation and inhibits the breakdown of noradrenaline by monoamine oxidase (MAO), preferentially the A-type enzyme. The effect on basal noradrenaline outflow disappeared when MAO was blocked by pargyline, while the effect on evoked release was absent in the presence of metitepine or phentolamine. These findings indicate that MeODMT acts both as a release enhancer and a metabolism inhibitor to boost noradrenaline activity.