Ibogaine induces glial activation in parasagittal zones of the cerebellum.
Neuroreport March 1, 1993 E O'Hearn, D B Long, M E Molliver 72 citations
Ibogaine, a drug proposed for treating addiction, activates glial cells in the cerebellum of rats, indicating possible neurotoxicity. After one to three doses of ibogaine (100 mg per kg of body weight), markers for microglia and astrocytes increased, and these cells changed shape. The activated glial cells appeared in striped patterns within the cerebellar vermis, suggesting degeneration of Purkinje neurons.