5-HT2/5-HT1C receptor-mediated facilitatory action on unit activity of ventral horn cells in rat spinal cord slices.
European journal of pharmacology September 22, 1992 J Yamazaki, H Fukuda, T Nagao et al. 38 citations
Certain drugs that activate serotonin receptors, specifically 5-HT2 and 5-HT1C types, increase the excitability of motor neurons in the spinal cord of adult rats. The compounds 5-MeODMT and DOI were the most potent at boosting the firing probability of these cells. Blocking 5-HT2 or 5-HT1C receptors with specific antagonists suppressed this effect, while blocking other serotonin receptor types did not. This indicates that 5-HT2 and 5-HT1C receptors mediate the facilitatory influence of serotonin-like drugs on spinal motor neuron activity.