American journal of public health
May 1, 2025
Karilynn M Rockhill, Joshua C Black, Janetta Iwanicki et al.
17 citations
In a 2022 nationally representative US survey of 15,800 adults, 20.9% reported using two or more drugs in the past year. Four distinct patterns emerged: medically guided use (11.5% of adults, 6.1% with substance use disorder), principal cannabis use (4.0%, 31.9% with disorder), self-guided nonmedical use (3.4%, 14.5% with disorder), and indiscriminate coexposures (2.1%, 58.9% with disorder). The findings reveal two previously unrecognized classes and indicate that many adults with polysubstance use have untreated substance use disorders. Prevention and treatment should be personalized to each person's specific drug-use profile.
Annals of emergency medicine
June 30, 2025
Joshua C Black, Karilynn M Rockhill, Evelyn J Fox et al.
4 citations
About one-third of US adults who used psychedelics in the past year traveled out of state to do so, primarily to Colorado and Oregon, which have decriminalized natural psychedelics. Travelers were more likely than nontravelers to report anxiety or depression symptoms and to have visited an emergency department or urgent care for a psychedelic-related issue. They were also more likely to use psychedelics for medical symptoms, at healing centers, or at ceremonial sites. Emergency physicians in both legalized and nonlegal states should be aware that travel for psychedelic use is common and may carry risks of adverse outcomes.
Journal of medical Internet research
April 27, 2026
Karilynn M Rockhill, Elizabeth A Bemis, Nicole Schow et al.
2 citations
Combining a large representative survey with a smaller survey focused on psychedelic drugs can produce generalizable estimates of rare behaviors like drug use without adding burdensome questions to the big survey. Researchers used calibration weighting to transport estimates from a psychedelic-enriched survey (two waves, total over 4,300 adults) to a representative anchor survey (two waves, total over 57,000 adults). The method showed good internal consistency, with transport biases under 0.4 percentage points for demographics, health, and substance use. External validity improved for health and substance use estimates after fusion. Using the fused data, recreational use of psilocybin (92.9%), LSD (93.2%), and MDMA (93.3%) was far more common than medical use (30.9%, 26.4%, and 21.1%, respectively). This approach expands surveillance epidemiology for rare behaviors.
Research square
May 19, 2026
Sunjuri Sun, Claudia Hanson, Peter S Hendricks et al.
The evidence on child and maternal outcomes after exposure to classic psychedelics during pregnancy is very sparse and of very low certainty. A systematic review of 42 studies, mostly case reports from high-income countries, found that LSD was the most commonly reported substance. Outcomes reported included spontaneous abortions (2 studies), stillbirth (1 study), neonatal mortality (16 studies), preterm birth (17 studies), birthweight (15 studies), and congenital malformations (26 studies). No maternal deaths were reported. Because of small sample sizes and varied study designs, no meta-analysis was possible. The authors conclude that methodologically rigorous research on psychedelic use during pregnancy is urgently needed.
Journal of psychoactive drugs
March 16, 2026
Faith E Lyons, Karilynn M Rockhill, Evelyn J Fox et al.
Adults who used a psychedelic in the past year most prefer surveys that use specific substance names (e.g., psilocybin, ayahuasca) over umbrella terms. In a cross-sectional survey of 2,306 respondents, specific substance names received the highest preference (median rank 3; 24.3% ranked first), followed by "psychedelics" (median rank 3; 19.4%). Terms like "hallucinogen," "medicines," and "entheogens" ranked lower. Preferences were consistent across age, education, and experience levels. The findings offer recommendations for terminology in future survey development.