Behavioral and electroencephalographic effects of a serotonin receptor agonist (5-methoxy-N,N-dimethyltryptamine) in a feline model of photosensitive epilepsy.
Neuroscience letters April 13, 1992 Y Wada, H Hasegawa, M Nakamura et al. 21 citations
A serotonin receptor agonist, 5-MeODMT, suppresses light-triggered muscle jerks but not abnormal EEG activity in kindled cats. At a dose of 4 mg/kg, the drug reduced photically induced myoclonus for 30 to 60 minutes after injection, accompanied by behavioral signs resembling serotonin syndrome. The findings indicate that serotonin, acting through 5-HT1 receptors, plays a key role in photosensitive epilepsy.