Ibogaine antagonizes cocaine-induced locomotor stimulation in mice.
Life sciences January 1, 1992 H Sershen, A Hashim, L Harsing et al. 65 citations
In mice, ibogaine reduced the increased movement caused by cocaine, both shortly after injection and 24 hours later, indicating the effect was not just short-term depression. When ibogaine was given after three days of daily cocaine, movement was still lower on days 5 and 9 without further ibogaine. Ibogaine did not affect amphetamine-induced movement. It transiently increased dopamine turnover, then decreased it in the striatum and frontal cortex after 24 hours. Ibogaine did not alter cocaine binding to its striatal site in vitro and had weak affinity there. The results suggest ibogaine may selectively change the dopamine system, reducing cocaine responsiveness for at least a week.