Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice.
Fundamental & clinical pharmacology January 1, 1992 B Francés, R Gout, J Cros et al. 46 citations
In mice, a tremor-inducing dose of ibogaine did not relieve pain on its own but made morphine more effective at relieving pain. In morphine-dependent mice, ibogaine did not reduce withdrawal symptoms; instead, it increased the number of vertical jumps caused by naloxone, a drug that triggers withdrawal. This effect was specific to opioid withdrawal, as ibogaine did not alter jumping caused by a different drug. The results indicate that ibogaine modulates morphine's pain-relieving effects but does not lessen opioid withdrawal signs in mice, contrasting with reports of it alleviating opiate dependence in humans.