Fundamental & clinical pharmacology
January 1, 1992
B Francés, R Gout, J Cros et al.
46 citations
In mice, a tremor-inducing dose of ibogaine did not relieve pain on its own but made morphine more effective at relieving pain. In morphine-dependent mice, ibogaine did not reduce withdrawal symptoms; instead, it increased the number of vertical jumps caused by naloxone, a drug that triggers withdrawal. This effect was specific to opioid withdrawal, as ibogaine did not alter jumping caused by a different drug. The results indicate that ibogaine modulates morphine's pain-relieving effects but does not lessen opioid withdrawal signs in mice, contrasting with reports of it alleviating opiate dependence in humans.
Fundamental & clinical pharmacology
April 1, 2025
Laïyna Lilo Aouichi, Elise Pape, Jean-Yves Jouzeau et al.
4 citations
About 2.6% of drivers who tested positive for drugs in roadside checks in northeastern France over 32 months (2020–2023) had ketamine in their oral fluid. Among 88 ketamine-positive drivers, 80.7% were male, 95.4% used multiple drugs, and their average age was 27.5 years. Ketamine concentrations averaged 821 ng/mL when norketamine was also present and 7.8 ng/mL when it was absent. Roughly 26% of ketamine-positive drivers had oral fluid levels potentially linked to impaired driving. The authors suggest adding ketamine and norketamine to routine oral fluid drug testing for driving under the influence.
Fundamental & clinical pharmacology
July 1, 2026
Nina Abukahok, Steven Lawrence, Samrachana Adhikari et al.
In the New York metropolitan area, over a third of clinics advertising ketamine for psychiatric conditions offer it for at-home use, raising safety concerns. A 2025 systematic web search identified 233 clinics; 36.5% prescribed ketamine for at-home use, 51.5% listed a medical doctor, 42.9% advertised oral ketamine, and depression was the most common condition treated (94.0%). Clinics advertising oral ketamine were over four times more likely to offer at-home use, while those listing a medical doctor were about half as likely. The findings suggest a consumer-oriented advertising approach that may warrant monitoring and clearer guidance to mitigate safety risks.