Opposite effects of 5-methoxy-N,N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior.
Pharmacology, biochemistry, and behavior January 1, 1991 S Ahlenius, K Larsson 31 citations
A dose of 5-MeODMT, a serotonin receptor agonist, reduced the number of intromissions before ejaculation and shortened ejaculation latency in male rats, indicating facilitated sexual behavior. This effect was blocked by pindolol, a 5-HT1 receptor antagonist, but not by pirenperone or metergoline, which block 5-HT2 receptors. In contrast, 5-HTP, a serotonin precursor, increased mounts and intromissions and lengthened ejaculation latency, an effect that was additive with pindolol. Betaxolol had no effect alone or with 5-HTP. The findings suggest that stimulating 5-HT1 receptors facilitates male rat sexual behavior, while stimulating 5-HT2 receptors inhibits it.