Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat.
Neuroreport September 1, 1990 L G Sharpe, J H Jaffe 79 citations
Ibogaine, despite anecdotal reports of eliminating opioid withdrawal symptoms in humans, did not alleviate opioid withdrawal in a rat model. Morphine-dependent rats received ibogaine at doses of 5, 10, 20, or 40 mg/kg before naloxone-precipitated withdrawal. Of twelve withdrawal signs scored, only two significant changes occurred: decreased grooming at 10 mg/kg and increased teeth chatter at 5 mg/kg. These results indicate that ibogaine does not reduce opioid withdrawal in this animal model at either non-tremorigenic or tremorigenic doses.