Characteristics and mental health of psychedelic mushroom and multi-psychedelic users relative to non-psychedelic users in American adults, 2020-2021.
Frontiers in psychiatry January 1, 2025 Sofia Abramsky-Sze, Elliot Marseille, Richard Matzopoulos et al. 4 citations
A cross-sectional survey of 6,869 American adults found that those who used psychedelic mushrooms in the past year reported lower mental health scores and higher levels of anxiety and depression than non-users. The 256 psychedelic users (3.7% of the sample) included 122 who used only psilocybin mushrooms and 134 who used multiple psychedelics; the multi-psychedelic group had the poorest mental health. These differences persisted even after controlling for past-year anxiety and depression, suggesting that psychedelic use is associated with poorer mental health in some contexts. The authors call for more population-based research on exclusive psilocybin and combined psychedelic use.