An in vivo dialysis and behavioural study of the release of 5-HT by p-chloroamphetamine in reserpine-treated rats.
British journal of pharmacology May 1, 1989 A Adell, G S Sarna, P H Hutson et al. 77 citations
In rats, reserpine depleted brain serotonin (5-HT) by 86% but did not block the behavioral syndrome caused by p-chloroamphetamine (PCA) or 5-MeODMT, except for changes in Straub tail and head weaving. Extracellular serotonin in the frontal cortex was about 1/1000th of brain levels before PCA, and PCA increased dialysate serotonin similarly in reserpine- and vehicle-pretreated rats. The results suggest PCA releases serotonin from the neuronal cytoplasm to produce the syndrome, while normal physiological release comes from vesicular stores.