B Fournier

2 papers in the library · 57 citations · publishing 1987-1988

Papers

Comparison of effects of some 5-HT1 agonists on blood pressure and heart rate of normotensive anaesthetized rats.

European journal of pharmacology August 21, 1987 H Dabiré, C Cherqui, B Fournier et al. 47 citations

In anaesthetized rats, three drugs that activate serotonin 1A receptors (8-OH-DPAT, 5-MeODMT, and TFMPP) all lowered blood pressure and heart rate after intravenous injection. For 5-MeODMT and TFMPP, a brief blood pressure increase preceded the decrease. The blood pressure drop from 5-MeODMT and 8-OH-DPAT was blocked by spiroxatrine but not by ketanserin or cocaine, suggesting it results from stimulating '5-HT1-like' receptors, likely the 5-HT1A subtype. The initial blood pressure rise from 5-MeODMT appears due to activating 5-HT2 receptors.

DOI: 10.1016/0014-2999(87)90282-2 Full text

Vascular postsynaptic effects of some 5-HT1-like receptor agonists in the pithed rat.

European journal of pharmacology May 20, 1988 H Dabiré, C Cherqui, B Fournier et al. 10 citations

In pithed rats, serotonin (5-HT) raised blood pressure, an effect blocked by LY 53857, a selective 5-HT2 receptor antagonist, but not by antagonists of 5-HT1-like, 5-HT3, alpha-2, or alpha-1 receptors. 5-MeODMT also increased blood pressure, though less potently than 5-HT, and this effect was similarly blocked by LY 53857. Other serotonin receptor agonists—8-OH-DPAT, RU 24969, and TFMPP—were far less effective at raising blood pressure, while 5-CT lowered blood pressure. These results suggest that vasoconstriction from 5-HT and 5-MeODMT in pithed rats is primarily mediated by postjunctional 5-HT2 receptors, with postjunctional 5-HT1-like receptors playing little or no role.

DOI: 10.1016/0014-2999(88)90760-1 Full text