The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory.
Pharmacology, biochemistry, and behavior August 1, 1987 J C Winter, D T Petti 128 citations
In a radial maze task, rats given various serotonergic drugs showed dose-related declines in response rate, except for a low dose of 8-OH-DPAT that increased responding. LSD, RU 24969, and 8-OH-DPAT also reduced efficiency, with 8-OH-DPAT being the most potent, producing efficiencies of 61%, 53%, and 44% at 0.3, 1.0, and 3.0 mg/kg, respectively. Given 8-OH-DPAT's selectivity for 5-HT1A receptors, the high density of these receptors in the hippocampus, and their reduction in Alzheimer's disease, the authors suggest this serotonin receptor subtype may play a role in memory.