Chemical and enzymatic oxidative coupling of 5-hydroxy-N,N-dimethyltryptamine with amines.
Journal of medicinal chemistry July 1, 1987 F Babin, T Huynh-Dinh 13 citations
An oxidative coupling method was developed to covalently label serotonin receptors. Oxidizing bufotenine with MnO2 or human ceruloplasmin, then adding dansylcadaverine or dansyllysine, produced a fluorescent adduct with a fused oxazole structure. This approach offers a way to attach fluorescent tags to serotonin derivatives for studying receptor binding.