Neocortical rhythmic slow activity during wakefulness and paradoxical sleep in rats.
Neuropsychobiology January 1, 1987 H Depoortere 14 citations
Neocortical rhythmic slow activity (RSA) during wakefulness and paradoxical sleep in rats occurs in two types: high-frequency (7-9 Hz) RSA1, which is atropine-resistant and abolished by urethane, clonidine, and alcuronium, and low-frequency (4-6 Hz) RSA2, which is atropine-sensitive and activated by cholinergic agents and drugs like tabernanthine, ibogaine, and vincamine. During paradoxical sleep, low-frequency RSAT correlates with tonic components, while high-frequency RSAp correlates with phasic phenomena such as rapid eye movements. Imipramine reduces RSAp, and alcuronium suppresses RSA1 during arousal but not RSAp, suggesting distinct central mechanisms. This approach may aid in treating vigilance and memory deficits and analyzing RSA in antidepressant and anxiolytic treatments.