Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine.
Psychopharmacology January 1, 1987 D G Spencer, T Glaser, J Traber 69 citations
Male Wistar rats learned to distinguish the effects of 5-OMe-DMT from saline in a two-lever operant chamber. Drugs that generalized to the 5-OMe-DMT stimulus included LSD, 8-OH-DPAT, BAY R 1531, ipsapirone, and buspirone, with potencies best correlating with binding affinities for the 5-HT1A serotonin receptor. Several other drugs did not generalize or did so only partially. Among serotonin receptor antagonists, only metitepine and pindolol fully blocked the 5-OMe-DMT stimulus. The data indicate strong involvement of the 5-HT1A receptor subtype in the interoceptive discriminative stimuli induced by 5-OMe-DMT, with a possible role for 5-HT2 agonism.