Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors.
Behavioral neuroscience October 1, 1986 L L Kwong, E R Smith, J M Davidson et al. 38 citations
Three prosexual drugs—8-OH-DPAT, 5-methoxy-dimethyltryptamine, and RDS-127—showed strong potential as selective inhibitors of 5-HT1A receptor binding, suggesting they may enhance seminal emissions and ejaculations. In contrast, yohimbine, imiloxan, and idazoxan primarily affected alpha 2-adrenergic receptors. The study analyzed interactions using radioligand binding techniques on rat brain membranes, providing insights into the mechanisms underlying sexual behavior. Understanding these interactions could pave the way for new treatments addressing sexual dysfunction.