Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome.
Pharmacology, biochemistry, and behavior June 1, 1986 L M Smith, S J Peroutka 245 citations
Four drugs that bind to the same serotonin receptor subtype (5-HT1A) produce different behavioral effects in rats. 8-OH-DPAT, 5-MeODMT, buspirone, and isapirone all potently inhibit 3H-8-OH-DPAT binding to rat brain membranes (Ki values = 1.9-13 nM). However, only 8-OH-DPAT and 5-MeODMT induce forepaw treading, head-weaving, and tremor, while buspirone and isapirone actually block those behaviors when given alongside the full agonists. All four drugs induce hindlimb abduction, flattened body posture, and Straub tail. The findings suggest that specific components of the serotonin behavioral syndrome are mediated by 5-HT1A receptors.