Indolealkylamines and prolactin secretion. A structure-activity study in the central nervous system of the rat.
Neuropharmacology December 1, 1985 G Seeman, G M Brown 5 citations
Indolealkylamine hallucinogens such as 5-methoxy-N,N-dimethyltryptamine (MDMT), bufotenin, and N,N-dimethyltryptamine (DMT) stimulate prolactin secretion when infused directly into the brain's lateral ventricle. MDMT is the most potent, followed by bufotenin, then DMT. Bufotenin, which does not easily cross the blood-brain barrier, produces a prolonged prolactin elevation with a possible biphasic effect at the highest dose (0.02 M). DMT shows a clear dose-response relationship. These findings confirm earlier work and suggest the effect is centrally mediated, not involving peripheral receptors, and that the time course of action differs from peripheral infusion.