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B Tandberg

2 papers in the library · 14 citations · publishing 1984-1985

Papers

Antagonism of 5-methoxy-N,N-dimethyltryptamine-induced changes in postdecapitation convulsions in rats by repeated treatment with drugs enhancing 5-hydroxytryptamine neurotransmission.

The Journal of pharmacy and pharmacology September 1, 1985 T Archer, B Tandberg, L Rènyi et al. 8 citations

Repeated administration of drugs that increase tryptaminergic neurotransmission blocked the effects of an acute injection of 5-MeODMT on postdecapitation convulsions in rats. Zimelidine, fluoxetine, amiflamine, and alpha-ethyltryptamine given orally over 10 days substantially blocked the increase in latency and duration of convulsions caused by 5-MeODMT, while alaproclate, clorgyline, and pargyline caused a lesser blockade. Repeated 5-MeODMT administration completely blocked the acute effects. These findings suggest down-regulation of serotonin receptors mediating the convulsion response and offer a simple model for studying receptor sensitivity changes at the spinal level.

DOI: 10.1111/j.2042-7158.1985.tb05103.x Full text

Effects of acute administration of 5-methoxy-N,N-dimethyltryptamine upon the latency and duration of post-decapitation convulsions.

Acta pharmacologica et toxicologica September 1, 1984 T Archer, B Tandberg 6 citations

An injection of the serotonin agonist drug 5-methoxy-N,N-dimethyltryptamine in rats lengthened both the time until and the duration of convulsions triggered by decapitation, starting at a dose of 0.5 mg/kg. Pretreatment with the serotonin antagonist methergoline (2.0 mg/kg) partially blocked these effects. Long-term administration of p-chloroamphetamine or p-chlorophenylalanine did not counteract the drug's effects but independently prolonged convulsion duration. The authors suggest the method may be useful for studying serotonin receptor mechanisms.

DOI: 10.1111/j.1600-0773.1984.tb02041.x Full text