Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents.
Life sciences December 17, 1984 R A Glennon, M Titeler, J D Mckenney 636 citations
The hallucinogenic potency of psychoactive agents, including LSD and related compounds, is closely linked to their ability to bind to 5-HT2 receptors in the brain. Binding affinities for 5-HT2 sites strongly correlated with both behavioral effects in animals (r = 0.938) and hallucinogenic potency in humans (r = 0.924). These findings indicate that activation of 5-HT2 receptors is a key mechanism underlying the hallucinogenic effects of these substances.