Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: effects on tremors induced by oxotremorine, harmine and ibogaine. A comparison with prolyl-leucylglycine amide (MIF), anti-Parkinsonian drugs and clonazepam.
Neuropharmacology June 1, 1983 G Zetler 18 citations
Cholecystokinin octapeptide (CCK-8), ceruletide, and ten of its analogues were more potent than several standard drugs (atropine, haloperidol, and others) at suppressing tremors caused by harmine or ibogaine in mice. However, these peptides were inactive against oxotremorine-induced tremors. The tremorolytic effect appeared independent of other central actions like hypothermia or sedation, suggesting CCK-like peptides may play a physiological role in regulating extrapyramidal motor activity.