Effects of apomorphine, clonidine or 5-methoxy-NN-dimethyltryptamine on approach and escape components of lateral hypothalamic and mesencephalic central gray stimulation in two inbred strains of mice.
Pharmacology, biochemistry, and behavior January 1, 1983 P Cazala, A M Garrigues 11 citations
Injecting mice with drugs that affect dopamine, serotonin, or norepinephrine alters their approach and escape behaviors triggered by brain stimulation. Apomorphine, which mimics dopamine, slowed both approach and escape reactions, more so in BALB/c mice. Clonidine, which mimics norepinephrine, sped up approach only in BALB/c mice. 5-m-DMT, which mimics serotonin, slowed escape in DBA/2 mice only. These results suggest that dopamine regulates escape from midbrain stimulation, serotonin modulates escape from both brain areas, and norepinephrine influences the appetitive component of hypothalamic stimulation. Approach and escape reactions depend on separate neuronal populations.