Inhibition of prolactin release by stimulation of presynaptic serotonin autoreceptors.
Life sciences December 6, 1982 J A Clemens, M E Roush 8 citations
In male rats, the serotonin agonist 5-MeODMT did not alter basal prolactin levels at doses from 1.0 to 20.0 mg/kg. However, pretreatment with 5-MeODMT reduced prolactin release stimulated by agents that rely on serotonergic neurotransmission, specifically L-5-hydroxytryptophan (5-HTP) and morphine. These results suggest that 5-MeODMT acts as a presynaptic serotonin autoreceptor stimulant rather than a post-synaptic serotonin agonist in the neuronal systems controlling prolactin release.