Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD.
European journal of pharmacology July 30, 1982 J Heym, G F Steinfels, B L Jacobs 21 citations
In freely moving cats, neurons in the dorsal raphe nucleus (DRN) are much more sensitive to the psychedelic compounds 5-MeO-DMT and LSD than neurons in the nucleus raphe pallidus (NRP). Low, behaviorally effective doses of these drugs strongly suppress activity in DRN neurons, while NRP neurons remain largely unaffected. This differential sensitivity suggests a unique autoregulatory control mechanism within distinct brain regions, where serotonin-producing neurons respond differently depending on their neuroanatomical location.