Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines.
Neuropharmacology October 1, 1982 R A Shephard, D A Buxton, P L Broadhurst 59 citations
Interactions between 5-MeODMT, chlordiazepoxide, and pCPA on conflict behavior were examined. 5-MeODMT at 1.0 and 3.0 mg/kg reduced unpunished response rates but did not affect punished behavior alone or with chlordiazepoxide. However, 5-MeODMT at 1 mg/kg reversed the anti-conflict effects of chronic pCPA (100 mg/kg). Chronic pCPA did not prevent increased punished responses from chlordiazepoxide (5 mg/kg). These findings suggest benzodiazepines act at a site distal to serotonergic drugs on conflict behavior.