Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
European journal of pharmacology February 26, 1982 C P Vandermaelen, G K Aghajanian 37 citations
In anesthetized rats, drugs that produce the behavioral serotonin syndrome—5-methoxy-N,N-dimethyltryptamine and p-chloroamphetamine—slowly depolarized facial motoneurons, increased their input resistance, and heightened their excitability. These effects match those seen when serotonin is applied directly to the same neurons, suggesting that such cellular changes contribute to some features of the serotonin syndrome.