Possible mechanism of 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in DRN lesioned rats.
Pharmacology, biochemistry, and behavior January 1, 1982 T P Blackburn, B Cox, C G Heapy et al. 4 citations
In rats with a unilateral lesion of the dorsal raphe nucleus (DRN), the compound 5-MeODMT caused turning toward the opposite side. This behavior was blocked by several serotonin antagonists, including methysergide, cyproheptadine, cinanserin, and the peripheral antagonist xylamidine. Among other neurotransmitter antagonists tested, only haloperidol was effective; hyoscine, picrotoxin, naloxone, and strychnine were not. Pretreatment with alpha-methyl-p-tyrosine also reduced the turning. These results suggest involvement of a central dopaminergic system. Additional lesions of the medial forebrain bundle with 6-OHDA changed the turning direction to the same side, supporting this interpretation.