[Modification of awake-sleep equilibrium by tabernanthine and some of its derivatives in the cat (author's transl)].
Revue d'electroencephalographie et de neurophysiologie clinique January 1, 1980 L Da Costa, I Sulklaper, R Naquet 4 citations
Four alkaloid derivatives of ibogamine were injected into the abdomens of cats with permanent brain electrodes. Tabernanthine tartrate and SAD 103 increased wakefulness, reduced slow wave sleep, and temporarily blocked paradoxical (REM) sleep. SAD 103's effects lasted much longer. The other two compounds, SAD 121 and SAD 122, had the opposite effect, slightly increasing both slow wave and paradoxical sleep. The findings suggest different ibogamine derivatives can either promote or suppress sleep stages, with implications for understanding the neurobiology of sleep.