Bufotenine esters.
Journal of medicinal chemistry November 1, 1979 R A Glennon, P K Gessner, D D Godse et al. 17 citations
Bufotenine, a psychoactive compound, has weak behavioral effects in humans and animals, likely because it cannot easily cross the blood-brain barrier. Researchers synthesized several ester derivatives of bufotenine to evaluate them pharmacologically. Unexpectedly, all the esters showed strong affinity for serotonin receptors in isolated rat stomach tissue. Chromatographic analysis indicated that the esters were not extensively broken down into bufotenine during the assay, suggesting the esters themselves may be active at these receptors.