High-affinity 3H-serotonin binding to caudate: inhibition by hallucinogens and serotoninergic drugs.
Psychopharmacology September 15, 1978 P M Whitaker, P Seeman 55 citations
Serotonin binds specifically to calf caudate tissue with high affinity, having a dissociation constant of 2 nM and a binding site density of 14 fmoles per milligram of protein. Among many drugs tested, only serotonin agonists and antagonists inhibited this binding. Agonist potencies ranged from bufotenin (6 nM) to tryptamine (270 nM), and antagonist potencies from LSD (9.5 nM) to metergoline (25 nM).