Preadministration of Lorazepam Reduces Efficacy and Longevity of Antidepressant-Like Effect from a Psychedelic.
Psychedelic medicine (New Rochelle, N.Y.) March 1, 2024 Meghan Hibicke, Gerald Billac, Charles D Nichols 2 citations
In male Wistar-Kyoto rats, intravenous psilocin (the active form of psilocybin) produced persistent antidepressant-like effects, reducing immobility in the forced swim test at both 3 and 14 weeks after a single dose. When lorazepam was given 30 minutes before psilocin, the antidepressant-like effect was present at 3 weeks but absent by 14 weeks, and the effect at 14 weeks was weaker than in rats given psilocin alone. Lorazepam therefore reduced both the magnitude and longevity of psilocin's antidepressant-like effects in this animal model.