Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network
NeuroImage Clinical January 1, 2018 Felix Mueller, Francesco Musso, Markus K. London et al. 65 citations
A subanesthetic dose of S-Ketamine, an NMDAR antagonist, alters resting-state brain connectivity in healthy men. In the executive control network, ketamine increased connectivity with the anterior cingulum and superior frontal gyrus, but these changes did not correlate with clinical symptoms. In the salience network, ketamine decreased connectivity with the calcarine fissure, and this decrease correlated with negative symptoms measured by the PANSS (R² > 0.4). The findings suggest that reduced salience network connectivity may serve as a predictive biomarker for ketamine-induced negative symptoms relevant to schizophrenia research.