Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine.
Scientific reports February 25, 2025 Joachim Neumann, Tobias Dietrich, Karyna Azatsian et al. 2 citations
Hallucinogenic tryptamines DMT and 5-MeO-DMT increase the force of contraction and beating rate in heart muscle tissue from mice engineered to overexpress human 5-HT4 receptors, and also increase force of contraction in human atrial tissue from cardiac surgery patients. These effects are smaller than those of serotonin, reaching about 65% of serotonin's maximum inotropic effect at 10 µM in mouse left atria, and 40 ± 5% of serotonin's chronotropic effect in mouse right atria. The drugs are inactive in wild-type mice. The potency of 5-MeO-DMT is enhanced by a phosphodiesterase inhibitor, and it increases phosphorylation of phospholamban at serine 16. DMT and 5-MeO-DMT act as partial agonists at human 5-HT4 receptors.