Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation
Psychopharmacology January 7, 2025 Mona Irrmischer, Drew Puxty, Hessel Engelbregt et al. 4 citations
A single high dose of psilocybin combined with therapy reduced symptoms of anxiety, depression, PTSD, and neuroticism over three months. Scores on openness and conscientiousness increased after treatment. Participants reported mystical-type experiences, emotional breakthrough, and personal growth, which—along with demographic factors—moderated the positive changes. The findings suggest psilocybin-assisted therapy can benefit mood and personality, and highlight the role of subjective experiences and demographics in optimizing this treatment.