Naturalistic Psychedelic Use and Psychotic Symptoms: A Cross-Sectional Study of Individuals with a Personal or Family History of Psychotic or Bipolar Disorders.
Psychedelic medicine (New Rochelle, N.Y.) June 1, 2025 Haley Maria Dourron, Melissa Bradley, Otto Simonsson et al. 7 citations
Greater lifetime psychedelic use was not associated with psychotic symptoms in a cross-sectional survey of 548 adults, even among those with a personal or family history of psychotic or bipolar disorders. In unadjusted analyses, more psychedelic use was linked to less referential thinking, but this association disappeared after adjusting for covariates. A personal history of psychotic disorders was tied to moderately greater magical ideation, referential thinking, and auditory hallucinations, while family history of psychotic disorders related to slightly greater negative symptoms. Notably, among individuals with a personal history of psychotic disorder, auditory hallucinations were less severe as psychedelic use increased, with no such relationship in those without that history. Naturalistic psychedelic use may not heighten psychosis risks.