Quantitative LC-QToF-MS Analysis of Mycochemicals in Amanita muscaria, Psilocybe spp. (Agaricomycetes), and Consumer Products.
International journal of medicinal mushrooms January 1, 2025 Kumar Katragunta, Bharathi Avula, Amar G Chittiboyina et al. 3 citations
A validated LC-QToF-MS method was developed to assess the quality and potential adulteration of Amanita muscaria and Psilocybe cubensis-based products. Analysis of 27 commercial products—including gummies, chocolates, capsules, tablets, and powders—revealed inconsistencies: 11 of 14 gummies claiming to contain Amanita extracts lacked ibotenic acid, containing only muscimol and muscarine; one gummy labeled "no psilocybin" contained psilocin and psilocybin; and five products contained none of the target compounds. Psilocin and psilocybin levels in Psilocybe samples ranged from 0.001-1.6% and 9.9-19.3%, respectively, while Amanita muscaria samples showed ibotenic acid, muscimol, and muscarine at 0.03-0.04%, 0.01-0.02%, and 0.01-0.02%. The findings underscore the need for standardized product specifications.